Scientific Evidence on Glucosamine

Journal of the American Medical Association, March 2000
After reviewing 15 trials on glucosamine and chondroitin for people suffering from joint pain/stiffness, researchers concluded that the compounds are both safe and do have some effectiveness in reducing joint stiffness and pains.

Journal of Rheumatology, Nov. 1999
Glucosamine hydrochloride benefits some patients with knee discomfort and pain.

Lancet, Nov. 1999
Correspondence on glucosamine indicates that short-term studies on glucosamine meet the guidelines of the Osteoarthritis Research Society and the requirements of a symptom modification trial showing that glucosamine can improve symptoms associated with Osteoarthritis.

Medical Hypotheses, June 1998
High-dose glucosamine may provide fast benefit in relieving pain and discomfort and in the long term aid repair of damaged cartilage.

Arthritis Rheumatology, 42; 1999
Glucosamine sulfate significantly reduces progression of knee pain and discomfort over 3 years.

Alternative Medical Review, Feb. 1998
Glucosamine sulfate's primary role appears to be directly due to its ability to stimulate the proteins in cartilage that bind water in the cartilage matrix (the "birthplace" of healthy cartilage) and the formation of the molecules that serve as the building blocks of cartilage.

Alternative Medicine Alert, Nov. 1998
Six double-blind investigations in five countries all have documented statistically significant benefits, without side effects on glucosamine sulfate.

Annals of Pharmacotherapy, 1998
Glucosamine sulfate is well absorbed and has a striking lack of side effects. Improvement in pain severity and range of motion due to usage of glucosamine has been observed in clinical trials. Data from short-term human trials suggest that glucosamine when administered orally has produced gradual and progressive reduction in joint pain and tenderness, as well as improved range of motion and walking speed.

Medical Hypothesis, May 1994
Glucosamine sulfate is a safe nutritional measure that supports proteoglycan synthesis.

Osteoarthritis and Cartilage, 1994
Glucosamine's mere presence acts as a stimulant to chondrocytes (cells that form cartilage) that produce the proteins that bind water in the cartilage matrix.

Journal of the American Academy of Orthopaedic Surgeons July/August 1994
Glucosamine has been shown to spur the chondrocytes (cells that form cartilage) to produce more collagen and proteoglycans, and it helps normalize cartilage metabolism, which helps to keep the cartilage from breaking down.

Current Medical Resource Opinion, 1982
In a double blind eight-week study of 40 patients with OA, glucosamine sulfate was as effective as 400 mg of ibuprofen in relieving pain after two weeks and by the end of the trial was more effective.

Pharmatherapeutica, 1982
Research shows that glucosamine can help to rebuild cartilage and help your body to control inflammation.